493 Triple negative status and progesterone receptor conversion between primary breast cancer and skin metastasis render worst survival among patients with stage 4 breast cancers

Background: Status of tumor receptor, including estrogen receptor(ER), progesterone receptor(PR) and Erb-B2 Receptor Tyrosine Kinase 2(ERBB2), is important to predict clinical behavior in breast cancer. Cutaneous metastasis from cancer a dismal sign. However, whether the receptor status would differ primary skin metastatic sites conversion affect remain unknown. Methods: From 2002 2021, 41 patients with biopsy-proven cutaneous were identified medical center Taiwan. 2004 869 stage 4 by registry same hospital. Demographics, presentations, survival time after measured. The ER, PR, ERBB2 tumors measured immunohistochemistry. Results: patients, 52 biopsied. median age at diagnosis was 56 years old (range: 33-82 old). most common both primary(75%) tumors(67%). ER-PR-ERBB2+(n=16, 46%), ER+PR+ERBB2+(n=8, 23%) ER+PR+ERBB2-(n=4, 11%). While metastasis, ER-PR-HER2+(n=13, 48%), ER+PR+HER2+(n=5, 19%) ER+PR-HER2+(n=4, 15%) common. all 28 months, which longer than that (10 months). Patients either or triple negative had 3 months. gain loss PR 4.5 Conclusion: There are high percentage presentation tumors. worst outcome among patients. second those conversion.